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产品信息
MA5-28197
产品规格
种属反应
Human
宿主/亚型
Hamster
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
A10
抗原
Fibroblast cell line ARH102 expressing CD97-EMR1 (EGF1-6)
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Lyophilized
纯化类型
Protein G
保存液
PBS with 1% BSA, 5% sucrose
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745168
产品详细信息
This antibody recognizes human EMR1 (EGF-like module containing, mucin-like, hormone receptor-like 1). EMR1 is a seven-span transmembrane protein which is a member of the EGF-TM7 family of receptors. The detailed structure and function of EMR1 is still unknown.
Reconstitute with 1.0 mL distilled water
靶标信息
F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adhesion G protein-coupled receptor E1; egf-like module containing, mucin-like, hormone receptor-like 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor
基因别名: ADGRE1; EMR1; TM7LN3
UniProt ID: (Human) Q14246
Entrez Gene ID: (Human) 2015
