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Immunogen sequence: MSLWESLGE SWMRPRSEWP REPQVPLYVP KFHSGWEPPV DVLQEAPWEV EGLASAPIEE VSPVSRQSIR NSQKHSPTSE PTPPGDALPP VSSPHTHRGC QPTPAMAKYV KILYDFTARN ANELSVLKDE VLEVLEDGRQ WWKLRSRSGQ AGYVPCNILG EARPEDAGAP FEQAGQKYWG PASPTHKLPP SFPGNKDELM QHMDEVNDEL IRKISNIRAQ PQRHFRVERS QPVSQPLTYE SGPDEVRAWL EAKAFSPRIV ENLGILTGPQ LFSLNKEELK KVCGEEGVRV YSQLTMQKAF LEKQQSGSEL EELMNKFHSM NQRRGEDS (389-715 aa encoded by BC002474)
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 related protein 2; EPS8-like 2; EPS8-like protein 2; EPS8-related protein 2
基因别名: AI042819; AW545405; EPS8L2; EPS8R2; PP13181
UniProt ID: (Human) Q9H6S3, (Mouse) Q99K30
Entrez Gene ID: (Human) 64787, (Mouse) 98845
分子生物学功能: scaffold/adaptor protein