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Proteintech
ERK1/2 Polyclonal Antibody
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产品信息
16443-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Chicken,
Human,
Mouse,
Pig,
Plant,
Rat,
Sheep
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ERK1/2 Fusion Protein Ag9772 (25-360 aa encoded by BC017832)
偶联物
形式
Liquid
浓度
0.34 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-43 kDa.
Immunogen sequence: YTNLSYIGE GAYGMVCSAY DNVNKVRVAI KKISPFEHQT YCQRTLREIK ILLRFRHENI IGINDIIRAP TIEQMKDVYI VQDLMETDLY KLLKTQHLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLLNTTCDL KICDFGLARV ADPDHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINLKARNY LLSLPHKNKV PWNRLFPNAD SKALDLLDKM LTFNPHKRIE VEQALAHPYL EQYYDPSDEP IAEAPFKFDM ELDDLPKEKL KELIFEETAR FQPGYRS (25-360 aa encoded by BC017832)
靶标信息
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
