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Immunogen sequence: MSSDDRHLG SSCGSFIKTE PSSPSSGIDA LSHHSPSGSS DASGGFGLAL GTHANGLDSP PMFAGAGLGG TPCRKSYEDC ASGIMEDSAI KC (1-91 aa encoded by BC131517)
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ERR beta-2; ERR-beta; ERRbeta; ERRbeta-2; estrogen receptor related 2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; estrogen-related receptor, beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2
基因别名: DFNB35; Err-2; ERR2; ERRb; ERRB2; ESRL2; ESRRB; Estrrb; NR3B2
UniProt ID: (Human) O95718, (Mouse) Q61539, (Rat) P11475
Entrez Gene ID: (Human) 2103, (Mouse) 26380, (Rat) 299210