Proteintech

ETS1 Monoclonal Antibody (4F2D4)

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ETS1 Antibody (66598-1-IG) in WB

HSC-T6 cells were subjected to SDS PAGE followed by western blot with 66598-1-Ig (ETS1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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产品信息

66598-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000-1:5,000

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免疫组化 (IHC)

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产品规格

种属反应

Human, Rat

已发表种属

Not Applicable

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

4F2D4

抗原

ETS1 Fusion Protein Ag2127 (1-272 aa encoded by BC017314)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MKAAVDLKP TLTIIKTEKV DLELFPSPDM ECADVPLLTP SSKEMMSQAL KATFSGFTKE QQRLGIPKDP RQWTETHVRD WVMWAVNEFS LKGVDFQKFC MNGAALCALG KDCFLELAPD FVGDILWEHL EILQKEDVKP YQVNGVNPAY PESRYTSDYF ISYGIEHAQC VPPSEFSEPS FITESYQTLH PISSEELLSL KYENDYPSVI LRDPLQTDTL QNDYFAIKQE VVTPDNMCMG RTSRGKLGGQ DSFESIESYD SCGQEMGKEE KQT (1-272 aa encoded by BC017314)

靶标信息

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent.

Blood advances

Luchtel RA,Zhao Y,Aggarwal RK,Pradhan K,Maqbool SB

Tue Oct 25 00:00:00 EDT 2022

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.

Molecular medicine (Cambridge, Mass.)

Lu L,Zhong Z,Gu J,Nan K,Zhu M,Miao C

Thu Jul 08 00:00:00 EDT 2021

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.

Molecular medicine (Cambridge, Mass.)

Lu L,Zhong Z,Gu J,Nan K,Zhu M,Miao C

Thu Jul 08 00:00:00 EDT 2021

生物信息学

蛋白别名: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1

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基因别名: c-ets-1; ETS-1; ETS1; Etsoncb; EWSR2; p54; Tpl1

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UniProt ID: (Human) P14921, (Rat) P41156

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Entrez Gene ID: (Human) 2113, (Rat) 24356

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功能

RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding winged helix/forkhead transcription factor

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