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产品信息
10684-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ETV4 Fusion Protein Ag0984 (1-207 aa encoded by BC007242)
偶联物
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MYLHTEGFS GPSPGDGAMG YGYEKPLRPF PDDVCVVPEK FEGDIKQEGV GAFREGPPYQ RRGALQLWQF LVALLDDPTN AHFIAWTGRG MEFKLIEPEE VARLWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCEPEA LFSLAFPDNQ RPALKAEFDR PVSEEDTVPL SHLDESPAYL PELAGPAQPF GPKGGYSY (1-207 aa encoded by BC007242)
靶标信息
ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU. 1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU. 1, although PU. 1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Adenovirus E1A enhancer-binding protein; E1A F; E1A-F; ETS translocation variant 4; ets variant gene 4 (E1A enhancer binding protein, E1AF); ets variant gene 4 (E1A enhancer-binding protein, E1AF); ETS variant protein 4; EWS protein/E1A enhancer binding protein chimera; PEA3 protein; Polyomavirus enhancer activator 3; POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4); Polyomavirus enhancer activator 3 homolog; polyomavirus enhancer activator-3; Protein PEA3
基因别名: AW414408; E1A-F; E1AF; ETV4; Pea-3; PEA3; PEAS3
UniProt ID: (Human) P43268, (Mouse) P28322
Entrez Gene ID: (Human) 2118, (Rat) 360635, (Mouse) 18612
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
transcription from RNA polymerase II promoter
motor neuron axon guidance
cell differentiation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
branching involved in mammary gland duct morphogenesis
regulation of branching involved in mammary gland duct morphogenesis
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of transcription, DNA-templated
transcription, DNA-templated
regulation of transcription, DNA-templated
