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Proteintech

EYA1 Polyclonal Antibody

11 篇参考文献

查看其他6个EYA1抗体

货号 22658-1-AP

此产品在中国无法购买

150 µL

抗体检测数据 (8)

Application

EYA1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 8

EYA1 Antibody (22658-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 22658-1-AP (EYA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EYA1 Antibody in Immunocytochemistry (ICC/IF)

EYA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EYA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EYA1 Antibody in Western Blot (WB)

EYA1 Antibody in Western Blot (WB)

EYA1 Antibody in Western Blot (WB)

EYA1 Antibody in Western Blot (WB)

EYA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

EYA1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HeLa cells using 22658-1-AP (EYA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EYA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney using 22658-1-AP (EYA1 antibody) at dilution of 1:50 (under 40x lens).

EYA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney using 22658-1-AP (EYA1 antibody) at dilution of 1:50 (under 10x lens).

EYA1 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 22658-1-AP ( EYA1 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

EYA1 Antibody in Western Blot (WB) — Mouse colon tissue were subjected to SDS PAGE followed by western blot with 22658-1-AP (EYA1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

EYA1 Antibody in Western Blot (WB) — NCCIT cell were subjected to SDS PAGE followed by western blot with 22658-1-AP (EYA1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

EYA1 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 22658-1-AP (EYA1 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

EYA1 Antibody in Immunoprecipitation (IP) — IP result of anti-EYA1 (IP:22658-1-AP, 4ug; Detection:22658-1-AP 1:300) with mouse kidney tissue lysate 5300ug.

产品信息

22658-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

-

查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

-

免疫细胞化学 (ICC/IF)

1:20-1:200

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

EYA1 Fusion Protein Ag18489 (1-300 aa encoded by BC121799)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MEMQDLTSP HSRLSGSSES PSGPKLGNSH INSNSMTPNG TEVKTEPMSS SETASTTADG SLNNFSGSAI GSSSFSPRPT HQFSPPQIYP SNRPYPHILP TPSSQTMAAY GQTQFTTGMQ QATAYATYPQ PGQPYGISSY GALWAGIKTE GGLSQSQSPG QTGFLSYGTS FSTPQPGQAP YSYQMQGSSF TTSSGIYTGN NSLTNSSGFN SSQQDYPSYP SFGQGQYAQY YNSSPYPAHY MTSSNTSPTT PSTNATYQLQ EPPSGITSQA VTDPTAEYST IHSPSTPIKD SDSDRLRRGS D (1-300 aa encoded by BC121799)

靶标信息

This gene encodes a member of the eyes absent family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.

Cell reports

Fang Q,Tian GG,Wang Q,Liu M,He L,Li S,Wu J

Tue Apr 25 00:00:00 UTC 2023

Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.

Stem cell research & therapy

Cui Q,Zhang D,Kong D,Tang J,Liao X,Yang Q,Ren J,Gong Y,Wu G

Tue May 26 00:00:00 UTC 2020

MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.

Journal of molecular neuroscience : MN

Gao J,Kang XY,Sun S,Li L,Gao DS

Sun Mar 01 00:00:00 UTC 2020

MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.

Journal of molecular neuroscience : MN

Gao J,Kang XY,Sun S,Li L,Gao DS

Sun Mar 01 00:00:00 UTC 2020

EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.

American journal of translational research

Kong D,Ma W,Zhang D,Cui Q,Wang K,Tang J,Liu Z,Wu G

Thu Oct 01 00:00:00 UTC 2020

EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.

American journal of translational research

Kong D,Ma W,Zhang D,Cui Q,Wang K,Tang J,Liu Z,Wu G

Thu Oct 01 00:00:00 UTC 2020

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.

Frontiers in oncology

Kong D,Li A,Liu Y,Cui Q,Wang K,Zhang D,Tang J,Du Y,Liu Z,Wu G,Wu K

Thu Oct 01 00:00:00 UTC 2020

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.

Frontiers in oncology

Kong D,Li A,Liu Y,Cui Q,Wang K,Zhang D,Tang J,Du Y,Liu Z,Wu G,Wu K

Thu Oct 01 00:00:00 UTC 2020

Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.

Clinical breast cancer

Cui Q,Kong D,Li Z,Ahiable P,Wang K,Wu K,Wu G

Mon Oct 01 00:00:00 UTC 2018

Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.

Clinical breast cancer

Cui Q,Kong D,Li Z,Ahiable P,Wang K,Wu K,Wu G

Mon Oct 01 00:00:00 UTC 2018

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

生物信息学

蛋白别名: Eyes absent; Eyes absent homolog 1; MGC141875; OTTHUMP00000195053

基因别名: BOP; BOR; BOS1; EYA1; OFC1

UniProt ID: (Human) Q99502, (Mouse) P97767

Entrez Gene ID: (Human) 2138, (Mouse) 14048

RNA binding protein tyrosine phosphatase activity protein binding metal ion binding phosphoprotein phosphatase activity hydrolase activity

参与通路

establishment of mitotic spindle orientation metanephros development branching involved in ureteric bud morphogenesis outflow tract morphogenesis double-strand break repair transcription, DNA-templated pattern specification process mesodermal cell fate specification sensory perception of sound anatomical structure morphogenesis response to ionizing radiation striated muscle tissue development histone dephosphorylation protein sumoylation cellular protein localization establishment or maintenance of apical/basal cell polarity peptidyl-tyrosine dephosphorylation aorta morphogenesis outer ear morphogenesis middle ear morphogenesis regulation of neuron differentiation positive regulation of DNA repair positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter neuron fate specification embryonic skeletal system morphogenesis semicircular canal morphogenesis positive regulation of epithelial cell proliferation pharyngeal system development lung epithelial cell differentiation otic vesicle morphogenesis positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development DNA repair regulation of transcription, DNA-templated protein dephosphorylation cellular response to DNA damage stimulus multicellular organism development organ morphogenesis chromatin modification ear morphogenesis inner ear morphogenesis cell fate commitment positive regulation of transcription, DNA-templated anatomical structure development otic vesicle development