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Endostatin Antibody (MA5-49582) in ELISA
ELISA analysis of Endostatin, microtiter wells were coated with Endostatin Monoclonal Antibody (KT58) (Product # MA5-49582) at 5 µg/mL. COL18A1 was used as the antigen. Peroxidase conjugated mouse anti-human COL18A1 monoclonal antibody (KT60) was used as the detection antibody. Result: KT58 and KT60 can be used as a matched antibody pair to detect and quantify the concentration of COL18A1.
产品信息
MA5-49582
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
KT58
抗原
Recombinant Human COL18A1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3090653
产品详细信息
This product was used in both Indirect and Sandwich ELISA.
靶标信息
Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antiangiogenic agent; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; MGC74745; multi-functional protein MFP
基因别名: COL18A1; KNO; KNO1; KS
UniProt ID: (Human) P39060
Entrez Gene ID: (Human) 80781
angiogenesis
endothelial cell morphogenesis
cell adhesion
visual perception
positive regulation of cell proliferation
negative regulation of cell proliferation
organ morphogenesis
extracellular matrix organization
positive regulation of cell migration
collagen catabolic process
response to drug
response to hydrostatic pressure
positive regulation of endothelial cell apoptotic process
