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产品信息
PA5-95282
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Eph receptor A5 (1001-1032aa TLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVN).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2807086
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
EPHA5 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e. g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e. g. ABL, FAK, JAK, and SRC families).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARCC2; Brain-specific kinase; CEK-7; CTPA; CTPP1; ECK; eck-like sequence 1; EHK-1; EK7; epa5; EPH homology kinase 1; EPH-like kinase 7; Ephrin A2; Ephrin A5; Ephrin type-A receptor 5; EphrinA2; EphrinA5; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1
基因别名: AI854630; AW125296; BSK; CEK7; EHK-1; EHK1; EK7; Ekh1; Els1; Els1.; EPHA5; HEK7; Rek7; TYRO4
UniProt ID: (Human) P54756, (Mouse) Q60629, (Rat) P54757
Entrez Gene ID: (Human) 2044, (Mouse) 13839, (Rat) 79208
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
ATP binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor receptor binding
transmembrane signal receptor
axon guidance
peptidyl-tyrosine phosphorylation
cAMP-mediated signaling
hippocampus development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
ephrin receptor signaling pathway
neuron development
regulation of insulin secretion involved in cellular response to glucose stimulus
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
negative regulation of synapse assembly
dendritic spine morphogenesis
