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产品信息
PA5-56744
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human EphA8. Recombinant protein control fragment (Product #RP-94014).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641067
产品详细信息
Immunogen sequence: KRHCGYSKAF QDSDEEKMHY QNGQAPPPVF LPLHHPPGKL PEPQFYAQPH TYEEPGRAGR SFTREIEASR IHIEKIIGSG DSG
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
靶标信息
EPHA8 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPHA8 plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
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生物信息学
蛋白别名: EK3; epa8; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH-like kinase 3; Ephrin type-A receptor 8; hydroxyaryl-protein kinase; protein-tyrosine kinase; Tyrosine-protein kinase receptor EEK; tyrosylprotein kinase
基因别名: EEK; EK3; EPHA8; HEK3; KIAA1459
UniProt ID: (Human) P29322
Entrez Gene ID: (Human) 2046
substrate-dependent cell migration
cell adhesion
axon guidance
neuron remodeling
peptidyl-tyrosine phosphorylation
regulation of cell adhesion
neuron projection development
regulation of cell adhesion mediated by integrin
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
protein autophosphorylation
ephrin receptor signaling pathway
