Invitrogen

ErbB4 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

高级验证 (1)

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ErbB4 Antibody (PA5-82452)

Relative expression in different tissues in IHC: Detection of differential expression levels of ErbB4 demonstrates antibody specificity. Immunohistochemical analysis of ErbB4 using anti-ErbB4 Polyclonal Antibody (Product #PA5-82452), shows significant staining of ErbB4 in testis and shows minimal or weak staining in liver tissues. The relative expression levels of ErbB4 within each tissue is shown using RN... View More

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ErbB4 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of ErbB4 demonstrates antibody specificity. Immunohistochemical analysis of ErbB4 using anti-ErbB4 Polyclonal Antibody (Product #PA5-82452), shows significant staining of ErbB4 in testis and shows minimal or weak staining in liver tissues. The relative expression levels of ErbB4 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-82452

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:50-1:200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ERBB4. Recombinant protein control fragment (Product #RP-88798).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Anitgen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2789610

产品详细信息

Immunogen sequence: LPSPNDSKFF QNLLDEEDLE DMMDAEEYLV PQAFNIPPPI YTSRARIDSN RNQFVYRDGG FAAEQGVSVP YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRK

靶标信息

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; ERBB4 transcript variant I12DEL; ERBB4 transcript variant I20DEL; human epidermal growth factor receptor 4; OTTHUMP00000209432; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

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基因别名: ALS19; ERBB4; HER4; p180erbB4

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UniProt ID: (Human) Q15303

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Entrez Gene ID: (Human) 2066

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