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产品信息
2056-MSM1-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
EPO, 1367
抗原
Recombinant fragment (around aa 28-162) of human EPO protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris Buffer with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epoetin; Erythropoietin; MGC138142
基因别名: EP; EPO; MVCD2
UniProt ID: (Human) P01588
Entrez Gene ID: (Human) 2056
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
acute-phase response
signal transduction
embryo implantation
aging
blood circulation
positive regulation of cell proliferation
response to salt stress
negative regulation of calcium ion transport into cytosol
positive regulation of neuron projection development
peptidyl-serine phosphorylation
erythrocyte differentiation
activation of protein kinase activity
response to lipopolysaccharide
response to vitamin A
response to testosterone
positive regulation of activated T cell proliferation
positive regulation of tyrosine phosphorylation of Stat5 protein
hemoglobin biosynthetic process
erythrocyte maturation
response to estrogen
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
response to axon injury
response to electrical stimulus
response to hyperoxia
regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
cellular hyperosmotic response
negative regulation of neuron death
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
negative regulation of erythrocyte apoptotic process
negative regulation of cation channel activity
