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F4/80 Antibody (605-790) in IHC (P)
Immunohistochemistry: Human placenta (FFPE) stained with Mouse anti- F4/80 (Cat# 605-790) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
产品信息
605-790
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
BM8
抗原
A synthetic peptide of human F4/80
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Positive control: Spleen
Cellular location: Membrane.
靶标信息
F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; egf-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71
基因别名: ADGRE1; DD7A5-7; EGF-TM7; EMR1; F4/80; Gpf480; Ly71; TM7LN3
UniProt ID: (Human) Q14246, (Mouse) Q61549, (Rat) Q5Y4N8
Entrez Gene ID: (Human) 2015, (Mouse) 13733, (Rat) 316137
