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Immunogen sequence: SCKDQLQSY ICFCLPAFEG RNCETHKDDQ LICVNENGGC EQYCSDHTGT KRSCRCHEGY SLLADGVSCT PTVEYPCGKI PILEKRNASK PQGRIVGGKV CPKGECPWQV LLLVNGAQLC GGTLINTIWV VSAAHCFDKI KNWRNLIAVL GEHDLSEHDG DEQSRRVAQV IIPSTYVPGT TNHDIALLRL HQPVVLTDHV VPLCLPERTF SERTLAFVRF SLVSGWGQLL DRGATALELM VLNVPRLMTQ DCLQQSRKVG DSPNITEYMF CAGYSDGSKD SCKGDSGGPH ATHYRGTWYL TGIVSWGQGC ATVGHFGVYT RVSQYIEWLQ KLMRSEPRPG VLLRAPFP (120-466 aa encoded by BC130468)
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; Proconvertin; Serum prothrombin conversion accelerator; SPCA
基因别名: AI132620; Cf7; F7; FVII; SPCA
UniProt ID: (Mouse) P70375, (Human) P08709
Entrez Gene ID: (Mouse) 14068, (Human) 2155
分子生物学功能:
serine protease