Invitrogen

FADS1 Recombinant Rabbit Monoclonal Antibody (JE55-63)

FADS1 Antibody in Immunocytochemistry (ICC/IF)

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FADS1 Antibody (MA5-42500) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of of FADS1 in PANC-1 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with FADS1 Recombinant Monoclonal Antibody (Product # MA5-42500) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue)... View More

FADS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

MA5-42500

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:100

流式细胞分析 (Flow)

1:50-1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JE55-63

抗原

Synthetic peptide within N-terminal Human FADS1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2911641

产品详细信息

Positive Control: Rat liver tissue lysate, mouse liver tissue lysate, mouse brain tissue lysate, rat lung tissue lysate, Hela cell lysate, A549 cell lysate, Hela, PANC-1, human liver carcinoma tissue, human thyroid tissue, human colon carcinoma tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human small intestine tissue, A549.

Subcellular Location: Mitochondrion, Endoplasmic reticulum membrane.

靶标信息

The protein encoded by this gene is a member of the fatty acid desaturase gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13. 1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Acyl-CoA (8-3)-desaturase; BC269730_2; D5D; delta(5) desaturase; Delta(5) fatty acid desaturase; delta-5 desaturase; delta-5 fatty acid desaturase; Fatty acid desaturase 1; FLJ38956; FLJ90273; linoleoyl-CoA desaturase (delta-6-desaturase)-like 1

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基因别名: 0710001O03Rik; A930006B21Rik; AI317215; D5D; DSD; FADS1; FADS6; FADSD5; LLCDL1; TU12

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UniProt ID: (Human) O60427, (Mouse) Q920L1, (Rat) Q920R3

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Entrez Gene ID: (Human) 3992, (Mouse) 76267, (Rat) 84575

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功能

C-5 sterol desaturase activity oxidoreductase activity omega-6 fatty acid desaturase activity linoleoyl-CoA desaturase activity acyl-CoA desaturase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water iron ion binding heme binding

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