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Peptide Sequence: KWGDRPVGGG PSAGPVQGLQ RLLEQAKSPG ELLRWLGQNP SKVRAHHYSV ALRRLGQLLG SRPRPPPVEQ VTLQDLSQLI IRNCPSFD
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Fas-activated serine/threonine kinase; FAST kinase
基因别名: FAST; FASTK
UniProt ID: (Human) Q14296
Entrez Gene ID: (Human) 10922