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产品信息
TA802934
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI13H4
抗原
Human recombinant protein fragment corresponding to amino acids 1-354 of human FBXW7 produced in E.coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: archipelago; Archipelago homolog; DKFZp686F23254; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL-10
基因别名: AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; FBXW7; hAgo; hCdc4; SEL-10; SEL10
UniProt ID: (Human) Q969H0
Entrez Gene ID: (Human) 55294
protein polyubiquitination
vasculature development
sister chromatid cohesion
negative regulation of triglyceride biosynthetic process
regulation of lipid storage
viral process
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
negative regulation of DNA endoreduplication
regulation of protein localization
positive regulation of epidermal growth factor-activated receptor activity
negative regulation of Notch signaling pathway
protein stabilization
positive regulation of ubiquitin-protein transferase activity
lipid homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of proteasomal protein catabolic process
regulation of cell cycle G1/S phase transition
regulation of mitophagy
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of protein targeting to mitochondrion
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of hepatocyte proliferation
negative regulation of SREBP signaling pathway
