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Immunogen sequence: IGGKYNRGLT VVVAFRELVE PRKQDADSLQ RAWTVGWCVE LLQAFFLVAD DIMDSSLTRR GQICWYQKPG VGLDAINDAN LLEACIYRLL KLYCREQPYY LNLIELFLQS SYQTEIGQTL DLLTAPQGNV DLVRFTEKRY KSIVKYKTAF YSFYLPIAAA MYMAGIDGEK EHANAKKILL EMGEFFQIQD DYLDLFGDPS VTGKIGTDIQ DNKCSWLVVQ CLQRATPEQY QILKENYGQK EAEKVARVKA LYEELDLPAV FLQYEEDSYS HIMALIEQYA APLPPAVFLG LARKIYKRRK; Positive Samples: 293T, HepG2, HeLa, MCF7, U-251MG, BxPC-3, Mouse liver, Mouse ovary, Rat liver, Rat testis; Cellular Location: Cytoplasm
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
基因别名: 6030492I17Rik; Ac2-125; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Rat) P05369, (Mouse) Q920E5
Entrez Gene ID: (Human) 2224, (Rat) 83791, (Mouse) 110196