Search Thermo Fisher Scientific
图: 1 / 1
Positive test controls include: HeLa, HT-1080, SW480, LO2, NIH/3T3, Mouse liver, Mouse heart, Rat brain. The target is usually found in the following locations: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Membrane, Nucleus, Peripheral membrane protein, cell cortex, cytoskeleton.
Immunogen sequence: YDITLPLLLD SLQKMQEEMI KALKGIFDEY SQITSLVTEE IVNVHKEIQM SVEQIDPSTE YNNFIDVHRT TAAKEQEIEF DTSLLEENEN LQANEIMWNN LTAESLQVML KTLAEELMQT QQMLLNKEEA VLELEKRIEE SSETCEKKSD IVLLLSQKQA LEELKQSVQQ LRCTEAKFSA QKELLEQKVQ ENDGKEPPPV VNYEEDARSV TSMERKERLS KFESIRHSIA GIIRSPKSAL GSSALSDMIS I
FER is a member of the FPS/FES family of non-receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: c-FER; EC 2.7.10.2; Feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-FER; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; Tyrosine kinase 3; tyrosine protein kinase FLK; Tyrosine-protein kinase Fer; Tyrosine-protein kinase FLK
基因别名: AV082135; C330004K01Rik; FER; Fert; Fert2; Flk; Flk_retired; p94-Fer; PPP1R74; TYK3
UniProt ID: (Human) P16591, (Mouse) P70451, (Rat) P09760
Entrez Gene ID: (Human) 2241, (Mouse) 14158, (Rat) 301737