Search Thermo Fisher Scientific
Immunogen sequence: MRALDDMDH EGRDTLAREE LRQGLSELPA IHDLHQGILE ELEERLSNWE SQQKVADVFL AREQGFDHHA THILQFDRYL GLLSENCLHS PRLAAAVREF EQSVQGGSQT AKHRLLRVVQ RLFQYQVLLT DYLNNLCPDS AEYDNTQGAL SLISKVTDRA NDSMEQGENL QKLVHIEHSV RGQGDLLQPG REFLKEGTLM KVTGKNRRPR HLFLMNDVLL YTYPQKDGKY RLKNTLAVAN MKVSRPVMEK VPYALKIETS ESCLMLSASS CAERDEWYGC LSRALPEDYK AQALAAFHHS VEIRERLGVS LGERPPTLVP VTHVMMCMNC GCDFSLTLRR H (923-1262 aa encoded by BC035364)
FGD5 activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. It mediates VEGF-induced CDC42 activation. It may regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation and may play a role in regulating the actin cytoskeleton and cell shape.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FYVE, RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23
基因别名: FGD5; ZFYVE23
UniProt ID: (Human) Q6ZNL6
Entrez Gene ID: (Human) 152273
分子生物学功能: G-protein modulator protein-binding activity modulator guanyl-nucleotide exchange factor