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Immunogen sequence: MLQHLNLDFH GAVMRALDDM DHEGRDTLAR EELRQGLSEL PAIHDLHQGI LEELEERLSN WESQQKVADV FLAREQGFDH HATHILQFDR YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 76%.
FGD5 activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. It mediates VEGF-induced CDC42 activation. It may regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation and may play a role in regulating the actin cytoskeleton and cell shape.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FYVE, RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23
基因别名: FGD5; ZFYVE23
UniProt ID: (Human) Q6ZNL6
Entrez Gene ID: (Human) 152273
分子生物学功能:
G-protein modulator
protein-binding activity modulator
guanyl-nucleotide exchange factor