Proteintech

FGF12 Polyclonal Antibody

FGF12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FGF12 Antibody (13784-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 13784-1-AP ( FGF12 Antibody) at dilution of 1:50 (under 40x lens).

FGF12 Antibody in Immunoprecipitation (IP)

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产品信息

13784-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

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免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

FGF12 Fusion Protein Ag4797 (1-181 aa encoded by BC022524)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MESKEPQLK GIVTRLFSQQ GYFLQMHPDG TIDGTKDENS DYTLFNLIPV GLRVVAIQGV KASLYVAMNG EGYLYSSDVF TPECKFKESV FENYYVIYSS TLYRQQESGR AWFLGLNKEG QIMKGNRVKK TKPSSHFVPK PIEVCMYREQ SLHEIGEKQG RSRKSSGTPT MNGGKVVNQD ST (1-181 aa encoded by BC022524)

靶标信息

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress.

Neurobiology of disease

Greguske EA,Maroto AF,Borrajo M,Palou A,Gut M,Esteve-Codina A,Barrallo-Gimeno A,Llorens J

Thu Jun 15 00:00:00 EDT 2023

Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain-of-function FHF1(FGF12) missense mutation.

Epilepsia

Velíšková J,Marra C,Liu Y,Shekhar A,Park DS,Iatckova V,Xie Y,Fishman GI,Velíšek L,Goldfarb M

Thu Jul 01 00:00:00 EDT 2021

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.

Scientific reports

Hanada Y,Nakamura Y,Ozono Y,Ishida Y,Takimoto Y,Taniguchi M,Ohata K,Koyama Y,Imai T,Morihana T,Kondo M,Sato T,Inohara H,Shimada S

Tue Jul 31 00:00:00 EDT 2018

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.

Scientific reports

Hanada Y,Nakamura Y,Ozono Y,Ishida Y,Takimoto Y,Taniguchi M,Ohata K,Koyama Y,Imai T,Morihana T,Kondo M,Sato T,Inohara H,Shimada S

Tue Jul 31 00:00:00 EDT 2018

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.

Scientific reports

Hanada Y,Nakamura Y,Ozono Y,Ishida Y,Takimoto Y,Taniguchi M,Ohata K,Koyama Y,Imai T,Morihana T,Kondo M,Sato T,Inohara H,Shimada S

Tue Jul 31 00:00:00 EDT 2018

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.

Scientific reports

Hanada Y,Nakamura Y,Ozono Y,Ishida Y,Takimoto Y,Taniguchi M,Ohata K,Koyama Y,Imai T,Morihana T,Kondo M,Sato T,Inohara H,Shimada S

Tue Jul 31 00:00:00 EDT 2018

生物信息学

蛋白别名: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; Myocyte-activating factor

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基因别名: AV114868; B230343J05Rik; FGF-12; FGF12; FGF12B; FHF-1; FHF1

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UniProt ID: (Human) P61328, (Mouse) P61329

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Entrez Gene ID: (Human) 2257, (Mouse) 14167

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功能

protein binding growth factor activity sodium channel regulator activity ion channel binding receptor binding fibroblast growth factor receptor binding heparin binding growth factor intercellular signal molecule

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