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产品信息
PA5-116495
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 143-288 of human FGF2 (NP_0019975)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901126
产品详细信息
Positive Samples: rat ovary
Immunogen sequence: PALPEDGGSG AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH IKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTD ECFFFERLES NNYNTYRSRK YTSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS
靶标信息
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
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生物信息学
蛋白别名: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; FGF-2; FGF-b; Fibroblast growth factor; Fibroblast growth factor 2; fibroblast growth factor 2 (basic); H-FGF-b-147; H-FGF-b-154; HBGF-2; Heparin-binding growth factor 2; M-FGF-b; prostatropin
基因别名: BFGF; FGF-2; FGF2; FGFB; HBGF-2
UniProt ID: (Human) P09038, (Mouse) P15655, (Rat) P13109
Entrez Gene ID: (Human) 2247, (Mouse) 14173, (Rat) 54250
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
cytokine activity
protein binding
growth factor activity
heparin binding
1-phosphatidylinositol-3-kinase activity
ligand-dependent nuclear receptor transcription coactivator activity
chemoattractant activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
receptor binding
growth factor
intercellular signal molecule
MAPK cascade
activation of MAPK activity
branching involved in ureteric bud morphogenesis
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
phosphatidylinositol biosynthetic process
chemotaxis
signal transduction
Ras protein signal transduction
nervous system development
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
organ morphogenesis
negative regulation of fibroblast migration
positive regulation of phospholipase C activity
regulation of phosphatidylinositol 3-kinase signaling
growth factor dependent regulation of skeletal muscle satellite cell proliferation
peptidyl-tyrosine phosphorylation
extracellular matrix organization
hyaluronan catabolic process
inositol phosphate biosynthetic process
somatic stem cell population maintenance
phosphatidylinositol-3-phosphate biosynthetic process
wound healing
positive regulation of cell fate specification
positive regulation of MAP kinase activity
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
embryonic morphogenesis
positive chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of cell division
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
chondroblast differentiation
negative regulation of wound healing
positive regulation of ERK1 and ERK2 cascade
positive regulation of sprouting angiogenesis
regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
activation of MAPKK activity
angiogenesis
organ induction
positive regulation of protein phosphorylation
multicellular organism development
negative regulation of cell proliferation
embryo development ending in birth or egg hatching
glial cell differentiation
positive regulation of endothelial cell migration
positive regulation of gene expression
substantia nigra development
positive regulation of cerebellar granule cell precursor proliferation
cell differentiation
lung development
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
regulation of retinal cell programmed cell death
positive regulation of smooth muscle cell proliferation
response to axon injury
stem cell development
positive regulation of epithelial cell proliferation
regulation of cell cycle
positive regulation of protein kinase B signaling
cardiac muscle cell proliferation
corticotropin hormone secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
mammary gland epithelial cell differentiation
angiogenesis involved in coronary vascular morphogenesis
positive regulation of canonical Wnt signaling pathway
aging
