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产品信息
PA1-24762
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to residues E(360) A L E E R P A V M T S P L K(373) of human FGFR1, with a C-terminal added lysine
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_780610
产品详细信息
PA1-24762 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.
靶标信息
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
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生物信息学
蛋白别名: 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; CD331; CD331 antigen; FGF Receptor; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; N-sam; Proto-oncogene c-Fgr
基因别名: bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD
UniProt ID: (Human) P11362
Entrez Gene ID: (Human) 2260
glycoprotein binding
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
heparin binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
protein complex binding
identical protein binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
cell adhesion molecule binding
transmembrane signal receptor
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
skeletal system development
angiogenesis
ureteric bud development
in utero embryonic development
organ induction
neuron migration
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
transcription, DNA-templated
protein phosphorylation
sensory perception of sound
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of phospholipase activity
positive regulation of phospholipase C activity
positive regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
stem cell population maintenance
motogenic signaling involved in postnatal olfactory bulb interneuron migration
ventricular zone neuroblast division
embryonic limb morphogenesis
midbrain development
neuron projection development
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
phosphatidylinositol-3-phosphate biosynthetic process
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
chordate embryonic development
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of GTPase activity
regulation of cell differentiation
positive regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of cell cycle
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
paraxial mesoderm development
regulation of lateral mesodermal cell fate specification
cell maturation
skeletal system morphogenesis
mesenchymal cell differentiation
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
auditory receptor cell development
branching involved in salivary gland morphogenesis
lung-associated mesenchyme development
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of stem cell proliferation
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
regulation of extrinsic apoptotic signaling pathway in absence of ligand
