Invitrogen

FGFR1 Polyclonal Antibody

查看其他47个FGFR1抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

PA5-87350

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human FGFR1 (NP_0755982)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.56 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2804085

产品详细信息

Immunogen sequence: IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIVYKM K; Positive Samples: Mouse brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus, Single-pass type I membrane protein, cytosol

靶标信息

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 2.7.10.1; Basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD331 antigen; FGF Receptor; FGF receptor-1; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; MFR; N-sam; Proto-oncogene c-Fgr

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基因别名: AW208770; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; Eask; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; KAL2; MFR; N-SAM; OGD

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UniProt ID: (Human) P11362, (Rat) Q04589, (Mouse) P16092

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Entrez Gene ID: (Human) 2260, (Rat) 79114, (Mouse) 14182

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功能
glycoprotein binding protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding protein complex binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development angiogenesis ureteric bud development in utero embryonic development organ induction neuron migration positive regulation of mesenchymal cell proliferation chondrocyte differentiation transcription, DNA-templated protein phosphorylation sensory perception of sound positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity positive regulation of phospholipase C activity positive regulation of neuron projection development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration ventricular zone neuroblast division embryonic limb morphogenesis midbrain development neuron projection development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development phosphatidylinositol-3-phosphate biosynthetic process inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of cell cycle protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation skeletal system morphogenesis mesenchymal cell differentiation regulation of sensory perception of pain positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway positive regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of extrinsic apoptotic signaling pathway in absence of ligand brain development salivary gland morphogenesis regulation of gene expression negative regulation of gene expression orbitofrontal cortex development central nervous system neuron development lung development regulation of cell proliferation positive regulation of transcription from RNA polymerase II promoter blood vessel morphogenesis generation of neurons phosphorylation vasculogenesis involved in coronary vascular morphogenesis
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