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This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Centrosomal protein 43; FGFR1 oncogene partner; fibroblast growth factor receptor 1 oncogene partner
基因别名: 4930553O10Rik; CEP43; FGFR1OP; FOP
UniProt ID: (Human) O95684, (Mouse) Q66JX5, (Rat) Q4V7C1
Entrez Gene ID: (Human) 11116, (Mouse) 75296, (Rat) 683722