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产品信息
BS-0676R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human FGFR4, amino acids 1-100.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD334; CTLA-2-beta protein; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; Protein-tyrosine kinase receptor MPK-11; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
基因别名: CD334; Fgfr-4; FGFR4; JTK2; Mpk-11; TKF
UniProt ID: (Human) P22455, (Rat) Q498D6, (Mouse) Q03142
Entrez Gene ID: (Human) 2264, (Rat) 25114, (Mouse) 14186
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
heparin binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of gene expression
regulation of extracellular matrix disassembly
regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
regulation of lipid metabolic process
phosphatidylinositol-3-phosphate biosynthetic process
glucose homeostasis
positive regulation of catalytic activity
positive regulation of GTPase activity
positive regulation of proteolysis
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
regulation of bile acid biosynthetic process
response to bile acid
regulation of cholesterol homeostasis
positive regulation of DNA biosynthetic process
organ induction
lung development
alveolar secondary septum development
protein phosphorylation
phosphorylation
