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This antibody recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10^9M.
Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C44H69NO12; FK-506; Fujimycin; Tacrolimus