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Immunogen sequence: MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID; Positive Samples: HeLa, MCF-7, BT-474; Cellular Location: Nucleus
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 25 kDa FK506-binding protein; 25 kDa FKBP; FK506 binding protein 3, 25kDa; FK506-binding protein 25, T-cell; FK506-binding protein 3; FK506-binding protein 3 (25kD); FKBP-3; Immunophilin FKBP25; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; rapamycin binding protein; Rapamycin-selective 25 kDa immunophilin; Rotamase
基因别名: FKBP-25; FKBP-3; FKBP25; FKBP3; PPIase
UniProt ID: (Human) Q00688
Entrez Gene ID: (Human) 2287