Bioss

FOXD Polyclonal Antibody

产品信息

BS-12193R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300

免疫组化（石蜡） (IHC (P))

1:200

免疫组化（冰冻） (IHC (F))

1:100-1:500

免疫细胞化学 (ICC/IF)

1:100-1:500

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human FOXD1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neutralize ectodermal cells directly. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BF-2; Brain factor 2; Forkhead box protein D1; FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4); Forkhead box protein D2; Forkhead box protein D3; Forkhead box protein D4; forkhead homolog 2; forkhead, drosophila, homolog-like 17; Forkhead, drosophila, homolog-like 8; forkhead, Drosophila, homolog-like 9; forkhead-like 17; forkhead-like 8; forkhead-related activator 4; forkhead-related activator 5; forkhead-related activator 9; Forkhead-related protein FKHL17; Forkhead-related protein FKHL8; Forkhead-related protein FKHL9; Forkhead-related transcription factor 4; Forkhead-related transcription factor 5; Forkhead-related transcription factor 9; FREAC-4; FREAC-5; FREAC-9; Hepatocyte nuclear factor 3 forkhead homolog 2; HFH-2; HFH-BF-2; HNF-3/forkhead homolog 2; HNF-3/forkhead homolog, brain factor 2; HNF3/FH transcription factor genesis; Mesoderm/mesenchyme forkhead 2; MF-2; Myeloid factor-alpha; Transcription factor FKH-2

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基因别名: AI385632; AI426778; AIS1; BF-2; CWH3; Fkh2; FKHL17; FKHL8; FKHL9; FOXD1; FOXD2; FOXD3; FOXD4; FOXD4A; FREAC-4; FREAC-5; FREAC-9; FREAC4; FREAC5; FREAC9; Genesis; Hfh10; HFH2; Hfhbf2; Mf2; VAMAS2