Invitrogen

FOXJ1 Polyclonal Antibody

图: 1 / 2

FOXJ1 Antibody (PA5-85557) in WB

Western blot analysis of FOXJ1 in A) 293T whole cell lysate, B) whole cell lysate of human FOXJ1-transfected 293T cells using FOXJ1 polyclonal antibody (Product # PA5-85557) using 30 µg of sample at a dilution of 1:5000. Prior to incubation with primary antibody, the sample was separated on 10% SDS-PAGE.

Product Image Gallery

产品信息

PA5-85557

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:10,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human FOXJ1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2792697

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (89%), Rat (89%), Bovine (95%).

Positive Control: human FOXJ1-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: fork head homologue 4; Forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4; MGC35202

查看更多收起

基因别名: FKHL13; FOXJ1; HFH-4; HFH4

查看更多收起

UniProt ID: (Human) Q92949

查看更多收起

Entrez Gene ID: (Human) 2302

查看更多收起

功能

transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding

参与通路