Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
NeoBiotechnologies
FOXL1/Forkhead Box Protein L1 (Transcription Factor) Monoclonal Antibody (PCRP-FOXL1-1F8)
产品信息
2299-MSM2-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
PCRP-FOXL1-1F8
抗原
Recombinant fragment (around aa104-258) of human FOXL1 protein.
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: HeLa or U87 cells.Ubiquitous tissue expression. Cellular Localization: Nucleus.
Specificity Comments: FOXL1 is a 337 amino acid protein encoded by the mouse gene FOXL1. FOXL1 belongs to the forkhead family and contains one forkhead DNA-binding domain. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. forkhead factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyers patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the Adenomatous Polyposis Coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.
Predicted to react in Rat
靶标信息
The forkhead domain is a 100-amino acid monomeric DNA binding motif originally identified as a region of homology between the Drosophila forkhead protein and rat HNF3. Pierrou et al. (1994) identified 7 human genes containing forkhead domains and designated them forkhead related activators (FREAC) 1 through 7.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FKH11; FKHL10; Forkhead box protein L1; Forkhead related transcription factor; forkhead-like 11; Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FREAC-7; FREAC6; JFJ-3
基因别名: FKH6; FKHL11; FOXL1; FREAC7
UniProt ID: (Human) Q12952
Entrez Gene ID: (Human) 2300
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
visceral mesoderm-endoderm interaction involved in midgut development
heart development
organ morphogenesis
regulation of Wnt signaling pathway
proteoglycan biosynthetic process
Peyer's patch morphogenesis
