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产品信息
MA1-23232
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4E7
抗原
Amino acids 242-655 of FKHR expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_558989
产品详细信息
Predicted molecular weight: ~70 kDa. Positive Control: Cos 1 cells transfected with human FKHR.
靶标信息
FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein. Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma. Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation. FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress. FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass. Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOX01A
基因别名: FKH1; FKHR; FOXO1; FOXO1A
UniProt ID: (Human) Q12778
Entrez Gene ID: (Human) 2308
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator binding
chromatin binding
protein binding
beta-catenin binding
ubiquitin protein ligase binding
sequence-specific DNA binding
protein phosphatase 2A binding
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
temperature homeostasis
cellular glucose homeostasis
transcription, DNA-templated
protein acetylation
autophagy
apoptotic process
cellular response to DNA damage stimulus
insulin receptor signaling pathway
cellular response to starvation
positive regulation of autophagy
endocrine pancreas development
cellular response to insulin stimulus
negative regulation of stress-activated MAPK cascade
cellular response to oxidative stress
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
positive regulation of apoptotic process
negative regulation of apoptotic process
fat cell differentiation
negative regulation of fat cell differentiation
positive regulation of gluconeogenesis
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
enamel mineralization
cellular response to hydrogen peroxide
cellular response to cold
cellular response to hyperoxia
cellular response to dexamethasone stimulus
cellular response to nitric oxide
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
response to fluoride
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
regulation of energy homeostasis
