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FOXP1 Antibody (PA5-118394) in IHC (P)
Immunohistochemistry (Paraffin) analysis of FOXP1 in paraffin-embedded human small intestine tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with FOXP1 polyclonal Antibody (Product # PA5-118394) at a dilution of 1:50 f... View More
产品信息
PA5-118394
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within C-terminal human FoxP1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2902984
靶标信息
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551
基因别名: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1
UniProt ID: (Human) Q9H334, (Mouse) P58462
Entrez Gene ID: (Human) 27086, (Mouse) 108655
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein self-association
metal ion binding
androgen receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
protein heterodimerization activity
negative regulation of B cell apoptotic process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of endothelial cell migration
osteoclast differentiation
response to lipopolysaccharide
regulation of tumor necrosis factor production
chemokine (C-C motif) ligand 2 secretion
osteoclast development
macrophage activation
monocyte activation
endothelial cell activation
regulation of monocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of smooth muscle cell proliferation
regulation of interleukin-1 beta secretion
regulation of inflammatory response
negative regulation of androgen receptor signaling pathway
T follicular helper cell differentiation
interleukin-21 secretion
regulation of defense response to bacterium
regulation of macrophage colony-stimulating factor production
regulation of endothelial tube morphogenesis
regulation of interleukin-12 secretion
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
positive regulation of mesenchymal cell proliferation
pre-B cell differentiation
positive regulation of immunoglobulin production
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
heart development
skeletal muscle tissue development
motor neuron axon guidance
anatomical structure morphogenesis
embryo development
lung development
immunoglobulin V(D)J recombination
sarcomere organization
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
positive regulation of epithelial cell proliferation
cardiac muscle cell differentiation
regulation of cardiac muscle cell proliferation
lung secretory cell differentiation
cardiovascular system development
regulation of lung goblet cell differentiation
negative regulation of lung goblet cell differentiation
positive regulation of cardiac muscle cell differentiation
