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产品信息
H00093986-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1F8
抗原
FOXP2 (NP_055306, 616 a.a. approximately 715 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Immunogen sequence: LAESSLPLLS NPGLINNASS GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC PMSLVTTANH SPELEDDREI EEEPLSEDLE
靶标信息
FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
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生物信息学
蛋白别名: CAG repeat protein 44; DKFZp686H1726; Forkhead box protein P2; forkhead/winged-helix transcription factor; OTTHUMP00000196932; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein
基因别名: CAGH44; FOXP2; SPCH1; TNRC10
UniProt ID: (Human) O15409
Entrez Gene ID: (Human) 93986
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
skeletal muscle tissue development
post-embryonic development
cerebellum development
caudate nucleus development
putamen development
cerebral cortex development
growth
vocal learning
camera-type eye development
negative regulation of transcription, DNA-templated
lung alveolus development
smooth muscle tissue development
righting reflex
positive regulation of epithelial cell proliferation involved in lung morphogenesis
