Invitrogen

FOXP3 Polyclonal Antibody, DyLight™ 650

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产品信息

PA5-22942

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

-

免疫组化（石蜡） (IHC (P))

1:50

-

免疫组化（冰冻） (IHC (F))

1:50

-

免疫细胞化学 (ICC/IF)

Assay-Dependent

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide made to the C-terminal region of human FOXP3 (between residues 400-431).

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偶联物

DyLight™ 650 DyLight™ 650 DyLight™ 650

激发/发射光谱

651/673 nm 查看光谱

形式

Liquid

浓度

0.85 mg/mL

纯化类型

Antigen affinity chromatography

保存液

50mM sodium borate

内含物

0.05% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11154329

产品详细信息

This antibody does not detect mouse FOXP3 in Western blot but does detect mouse tissue for IHC.

靶标信息

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Forkhead box protein P3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; MGC141961; MGC141963; RP23-54C14.1; Scurfin; scurfy

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基因别名: AIID; DIETER; FOXP3; IPEX; JM2; PIDX; scurfin; sf; XPID

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UniProt ID: (Human) Q9BZS1, (Mouse) Q99JB6

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Entrez Gene ID: (Human) 50943, (Mouse) 20371

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RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription corepressor activity protein binding histone acetyltransferase binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding metal ion binding NF-kappaB binding NFAT protein binding nucleic acid binding DNA binding

参与通路

negative regulation of transcription from RNA polymerase II promoter B cell homeostasis cytokine production myeloid cell homeostasis CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment T cell mediated immunity tolerance induction to self antigen regulation of T cell anergy positive regulation of T cell anergy negative regulation of chronic inflammatory response negative regulation of T cell cytokine production positive regulation of peripheral T cell tolerance induction chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell proliferation response to virus negative regulation of histone deacetylation negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-gamma production negative regulation of interleukin-10 production negative regulation of interleukin-17 production negative regulation of interleukin-2 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interleukin-4 production negative regulation of CREB transcription factor activity positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transforming growth factor beta1 production positive regulation of immature T cell proliferation in thymus positive regulation of histone acetylation negative regulation of histone acetylation negative regulation of cytokine biosynthetic process T cell activation negative regulation of T cell proliferation T cell homeostasis negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of interferon-gamma biosynthetic process negative regulation of interleukin-2 biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of activated T cell proliferation negative regulation of isotype switching to IgE isotypes regulation of isotype switching to IgG isotypes negative regulation of cytokine secretion negative regulation of immune response T cell receptor signaling pathway negative regulation of T-helper 17 cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation tolerance induction regulation of immunoglobulin production positive regulation of T cell tolerance induction regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter anatomical structure morphogenesis positive regulation of gene expression regulatory T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of lymphocyte proliferation negative regulation of inflammatory response