Invitrogen

FSHR Monoclonal Antibody (3D5G9)

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FSHR Antibody (MA5-38525) in WB

Western Blot analysis of FSHR using FSHR Monoclonal Antibody (Product # MA5-38525) in HEK293 (1) and FSHR (AA: 18-366)-human IgG-Fc transfected HEK293 (2) cell lysate.

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产品信息

MA5-38525

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

流式细胞分析 (Flow)

1:200-1:400

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3D5G9

抗原

Purified recombinant fragment of human FSHR (aa: extra 18-366) expressed in E. Coli.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898438

产品详细信息

This antibody has been tested in indirect ELISA.

靶标信息

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。