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Factor VIII Antibody (MA1-10589) in ICC/IF
PloS one 2016 -
Fig 10 Less FVIII is bound to secreted/anchored ULVWF strings from stimulated HUVECs compared to GMVECs. HUVECs were stimulated with 100muM histamine for 2 min. Cells were then stained as described in the legend for Fig 9 with rabbit anti-VWF plus chicken anti-rabbit IgG AF-488 (green), and with mouse monoclonal anti-FVIII plus goat anti-mouse IgG AF-647 (red). Panels (A, C and E) show representative ULVWF ... View More
产品信息
MA1-10589
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
F8-5.5.72
抗原
Purified human Factor VIII.
偶联物
形式
Liquid
浓度
1.1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1074337
产品详细信息
MA1-10589 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor.
MA1-10589 has been successfully used in ELISA and Western blot applications.
The MA1-10589 immunogen is purified human Factor VIII.
靶标信息
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; Factor 8; factor VIII F8B; factor8; Procoagulant component; RP11-115M6.7
基因别名: AHF; DXS1253E; F8; F8B; F8C; FVIII; HEMA
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
