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Factor XIII B Antibody (PA5-97725) in WB
Western Blot analysis of Factor XIII B using a Factor XIII B Polyclonal antibody (Product # PA5-97725) at a concentration of 4.17 µg/mL. Positive WB detected in: 293 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 76 kDa.
产品信息
PA5-97725
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Coagulation factor XIII B chain protein (260-403AA)
偶联物
形式
Liquid
浓度
4.17 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812340
靶标信息
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation factor XIII B chain; coagulation factor XIII, B polypeptide; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; TGase; Transglutaminase B chain
基因别名: F13B; FXIIIB
UniProt ID: (Human) P05160
Entrez Gene ID: (Human) 2165
