Proteintech

FcRn Polyclonal Antibody

FcRn Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FcRn Antibody (16190-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using (Product # 16190-1-AP) (FcRn-Specific antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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产品信息

16190-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

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免疫组化（石蜡） (IHC (P))

1:1,000

免疫细胞化学 (ICC/IF)

Assay-dependent

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产品规格

种属反应

Human

已发表种属

Dog, Guinea pig

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.28 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

靶标信息

FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It plays a possible role in transfer of immunoglobulin G from mother to fetus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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International journal of molecular sciences

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Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

Cell

Zhao X,Zhang G,Liu S,Chen X,Peng R,Dai L,Qu X,Li S,Song H,Gao Z,Yuan P,Liu Z,Li C,Shang Z,Li Y,Zhang M,Qi J,Wang H,Du N,Wu Y,Bi Y,Gao S,Shi Y,Yan J,Zhang Y,Xie Z,Wei W,Gao GF

Thu May 30 00:00:00 EDT 2019

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy.

Clinical & developmental immunology

Struble EB,Ma L,Zhong L,Lesher A,Beren J,Zhang P

Thu Jan 31 00:00:00 EST 2013

Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy.

Clinical & developmental immunology

Struble EB,Ma L,Zhong L,Lesher A,Beren J,Zhang P

Thu Jan 31 00:00:00 EST 2013

生物信息学

蛋白别名: Fc fragment of IgG, receptor, transporter, alpha; FcRn; FcRn alpha chain; heavy chain of the major histocompatibility complex class I-like Fc receptor; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig; transmembrane alpha chain of the neonatal receptor

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基因别名: alpha-chain; FCGRT; FCRN

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UniProt ID: (Human) P55899

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Entrez Gene ID: (Human) 2217

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功能

antigen binding IgG receptor activity IgG binding beta-2-microglobulin binding peptide antigen binding major histocompatibility complex protein

参与通路

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor immune response antigen processing and presentation Fc-gamma receptor signaling pathway