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FTH1 is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; ferritin heavy chain 1; Ferritin subunit H; ferritin, heavy polypeptide 1; frih; MGC104426; placenta immunoregulatory factor; proliferation-inducing protein 15
基因别名: FHC; FTH; FTH1; FTHL6; HFE5; OK/SW-cl.84; PIG15; PLIF
UniProt ID: (Human) P02794, (Rat) P19132
Entrez Gene ID: (Human) 2495, (Rat) 25319