Invitrogen

Ferroportin Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

2个已发表图片

3 篇参考文献

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

Ferroportin Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

Ferroportin Antibody (PA5-64232) in ICC/IF

Immunofluorescent staining of SLC40A1 in human cell line U-2 OS using a SLC40A1 Polyclonal Antibody (Product # PA5-64232) shows localization to plasma membrane and cytosol.

Ferroportin Antibody in Immunohistochemistry (IHC)

Ferroportin Antibody in Western Blot (WB)

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产品信息

PA5-64232

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1µg/mL

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

1:1,000-1:2,500

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human SLC40A1. Recombinant protein control fragment (Product #RP-104220).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.40 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2647507

产品详细信息

Immunogen sequence: VKAGLKEEET ELKQLNLHKD TEPKPLEGTH LMGVKDSNIH ELEHEQEPTC ASQMAEPFRT FRDGWVSYYN

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.

靶标信息

SLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in SLC40A1 cause hemochromatosis type 4 (HFE4), which is an autosomal dominant iron-loading disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement.

International journal of molecular sciences

Raia S,Conti A,Zanardi A,Ferrini B,Scotti GM,Gilberti E,De Palma G,David S,Alessio M

Published figure using Ferroportin polyclonal antibody (Product # PA5-64232) in Western Blot

Fri Jan 06 00:00:00 EST 2023

Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.

Cell reports

Sterling JK,Kam TI,Guttha S,Park H,Baumann B,Mehrabani-Tabari AA,Schultz H,Anderson B,Alnemri A,Chou SC,Troncoso JC,Dawson VL,Dawson TM,Dunaief JL

PA5-64232 was used in Western Blotting to suggest that IL-6-induced CISR leads to toxic neuronal iron accumulation, contributing to synuclein-induced neurodegeneration.

Tue Feb 15 00:00:00 EST 2022

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value.

Frontiers in oncology

Zacchi P,Belmonte B,Mangogna A,Morello G,Scola L,Martorana A,Borelli V

PA5-64232 was used in Immunohistochemistry to shed a light on the complex mechanisms of local iron handling lung cancer can exploit to support tumorigenesis.

Tue Jun 08 00:00:00 EDT 2021

生物信息学

蛋白别名: Ferroportin; Ferroportin-1; iron regulated gene 1; Iron-regulated transporter 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 40 (iron-regulated transporter), member 1; Solute carrier family 40 member 1

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基因别名: FPN; FPN1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3; SLC40A1

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UniProt ID: (Human) Q9NP59

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Entrez Gene ID: (Human) 30061

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功能

receptor activity iron ion transmembrane transporter activity protein binding ferrous iron transmembrane transporter activity peptide hormone binding iron channel activity secondary carrier transporter

参与通路

lymphocyte homeostasis endothelium development cellular iron ion homeostasis regulation of transcription from RNA polymerase II promoter in response to iron iron ion transmembrane transport negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter spleen trabecula formation multicellular organismal iron ion homeostasis ferrous iron export