Invitrogen

Fibrinogen Polyclonal Antibody

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产品信息

PA5-141128

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

流式细胞分析 (Flow)

1:50-1:100
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Native protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2932580

靶标信息

Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: epididymis secretory sperm binding protein Li 78p; fibg; Fibrinogen alpha chain; Fibrinogen beta chain; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, A alpha polypeptide; fibrinogen, B beta polypeptide; fibrinogen, gamma polypeptide; gamma-fibrinogen; MGC119422; MGC119423; MGC119425; testicular tissue protein Li 70

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基因别名: 2510049G14Rik; 3010002H13Rik; AI256424; ENSMUSG00000059807; FGA; FGB; FGG; Fib; Fib2; HEL-S-78p; PRO2061

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UniProt ID: (Human) P02671, (Human) P02675, (Human) A8K057, (Mouse) E9PV24, (Mouse) Q8K0E8, (Mouse) Q8VCM7

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Entrez Gene ID: (Human) 2243, (Human) 2244, (Human) 2266, (Mouse) 14161, (Mouse) 110135, (Mouse) 99571

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功能
receptor binding structural molecule activity protein binding protein binding, bridging metal ion binding cell adhesion molecule binding chaperone binding intercellular signal molecule
参与通路
adaptive immune response platelet degranulation protein complex assembly acute-phase response cell-matrix adhesion signal transduction blood coagulation extracellular matrix organization plasminogen activation response to estradiol response to genistein positive regulation of heterotypic cell-cell adhesion fibrinolysis induction of bacterial agglutination response to morphine cellular protein complex assembly cellular protein metabolic process innate immune response positive regulation of vasoconstriction positive regulation of exocytosis response to cycloheximide positive regulation of protein secretion protein polymerization response to calcium ion positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to interleukin-6 cellular response to organic cyclic compound blood coagulation, common pathway blood coagulation, fibrin clot formation positive regulation of peptide hormone secretion liver regeneration positive regulation of substrate adhesion-dependent cell spreading negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular response to granulocyte colony-stimulating factor negative regulation of endothelial cell apoptotic process cellular response to leptin stimulus cellular response to interleukin-1 protein secretion immune system process hemostasis platelet activation
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