Invitrogen

Fibrinogen Beta Chain Polyclonal Antibody

查看其他16个FIBB抗体

抗体检测数据 (3)

Fibrinogen Beta Chain Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Fibrinogen Beta Chain Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Fibrinogen Beta Chain Antibody (PA5-119115) in IHC (P)

Immunohistochemistry analysis of Fibrinogen in paraffin-embedded Human Liver tissue. Samples were incubated with polyclonal antibody (Product # PA5-119115) at a dilution of 10 µg/mL.

Fibrinogen Beta Chain Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Fibrinogen Beta Chain Antibody in Western Blot (WB)

Fibrinogen Beta Chain Antibody in Western Blot (WB)

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Fibrinogen Beta Chain Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Fibrinogen in paraffin-embedded Human Liver tissue. Samples were incubated with polyclonal antibody (Product # PA5-119115) at a dilution of 10 µg/mL.

Fibrinogen Beta Chain Antibody in Western Blot (WB) — Western blot analysis of Fibrinogen in Lane 1: Wild-type HeLa cell lysate; Lane 2: FGb knockout HeLa cell lysate. Samples were incubated with polyclonal antibody (Product # PA5-119115) at a dilution of 2 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL. Predicted MW: 56 kDa; Observed MW: 56 kDa.

Fibrinogen Beta Chain Antibody in Western Blot (WB) — Western blot analysis of Fibrinogen in recombinant human FGb. Sample was incubated with polyclonal antibody (Product # PA5-119115).

产品信息

PA5-119115

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫组化（石蜡） (IHC (P))

5-20 µg/mL

-

免疫细胞化学 (ICC/IF)

5-20 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein Fibrinogen Beta Chain. The antigen corresponds to amino acid range 29-491 of the target protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2903615

靶标信息

FIBB is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: epididymis secretory sperm binding protein Li 78p; Fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405

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基因别名: FGB; HEL-S-78p

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UniProt ID: (Human) P02675

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Entrez Gene ID: (Human) 2244

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receptor binding structural molecule activity protein binding protein binding, bridging cell adhesion molecule binding chaperone binding intercellular signal molecule

参与通路

adaptive immune response platelet degranulation cell-matrix adhesion signal transduction blood coagulation extracellular matrix organization plasminogen activation positive regulation of heterotypic cell-cell adhesion fibrinolysis induction of bacterial agglutination cellular protein complex assembly cellular response to leptin stimulus innate immune response positive regulation of vasoconstriction positive regulation of exocytosis positive regulation of protein secretion protein polymerization response to calcium ion positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to interleukin-1 blood coagulation, fibrin clot formation positive regulation of peptide hormone secretion positive regulation of substrate adhesion-dependent cell spreading negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process