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Folliculin Antibody (PA5-100247) in ICC/IF
Immunofluorescent analysis of Folliculin in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Folliculin polyclonal antibody (Product # PA5-100247) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 4... View More
产品信息
PA5-100247
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FLCN(Accession Q8NFG4), corresponding to amino acid residues S56-Y106.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815777
产品详细信息
Antibody detects endogenous levels of total FLCN.
靶标信息
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Birt-Hogg-Dube syndrome protein homolog; Folliculin
基因别名: AU014660; B430214A04Rik; BHD; FLCL; FLCN
UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3, (Rat) Q76JQ2
Entrez Gene ID: (Human) 201163, (Mouse) 216805, (Rat) 303185
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
regulation of protein phosphorylation
positive regulation of protein phosphorylation
cell-cell junction assembly
positive regulation of autophagy
negative regulation of gene expression
negative regulation of mitochondrion organization
hemopoiesis
negative regulation of cell growth
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
TOR signaling
regulation of TOR signaling
negative regulation of TOR signaling
positive regulation of TOR signaling
regulation of cytokinesis
negative regulation of Rho protein signal transduction
regulation of histone acetylation
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
negative regulation of protein kinase B signaling
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein localization to nucleus
negative regulation of cell proliferation involved in kidney development
negative regulation of energy homeostasis
regulation of pro-B cell differentiation
negative regulation of ATP biosynthetic process
negative regulation of angiogenesis
negative regulation of transcription, DNA-templated
negative regulation of cellular respiration
negative regulation of mitochondrial DNA metabolic process
negative regulation of muscle tissue development
negative regulation of post-translational protein modification
positive regulation of intrinsic apoptotic signaling pathway
biological_process
