Invitrogen

Fyn Monoclonal Antibody (FYN-01)

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

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4 篇参考文献
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产品信息

MA1-19331

应用
建议稀释比
已发表文章

免疫印迹 (WB)

2 µg/mL
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免疫组化（石蜡） (IHC (P))

5 µg/mL
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse

已发表种属

Hamster, Human, Mouse

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

FYN-01

抗原

Recombinant fragment of human Fyn (aa 7-176)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1074491

产品详细信息

This antibody recognizes Fyn, a 59 kDa non-receptor Src-family protein tyrosine kinase (intracellular antigen).

Immunoprecipitation: Preparation of cell lysate: 30 min on ice (orbital incubator) in lysing buffer, lysing buffer with N-dodecyl beta-D-maltoside (20 mM Tris/Cl, 100 mM NaCl pH 8,2, 1% laurylmaltosid (w/v), 50 mM NaF). The antibody FYN-01 apparently gives very specific signal (by 59 kDa), and nicely immunoprecipitants Fyn from cell lysates.

靶标信息

FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn

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基因别名: AI448320; AW552119; FYN; p59-FYN; SLK; SYN

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UniProt ID: (Human) P06241, (Mouse) P39688

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Entrez Gene ID: (Human) 2534, (Mouse) 14360

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功能
G-protein coupled receptor binding glycoprotein binding protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding tubulin binding T cell receptor binding CD4 receptor binding CD8 receptor binding phosphatidylinositol 3-kinase binding ion channel binding metal ion binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity peptide hormone receptor binding growth factor receptor binding nucleotide binding protein kinase activity receptor binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein complex binding kinase modulator
参与通路
MAPK cascade neuron migration stimulatory C-type lectin receptor signaling pathway adaptive immune response protein phosphorylation calcium ion transport transmembrane receptor protein tyrosine kinase signaling pathway axon guidance central nervous system development blood coagulation learning feeding behavior regulation of cell shape negative regulation of gene expression positive regulation of neuron projection development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling viral process cell migration peptidyl-tyrosine phosphorylation cell differentiation platelet activation forebrain development T cell costimulation negative regulation of protein ubiquitination intracellular signal transduction cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis T cell activation regulation of cell proliferation negative regulation of protein catabolic process response to drug positive regulation of tyrosine phosphorylation of Stat5 protein regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity innate immune response response to ethanol phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling dendrite morphogenesis regulation of defense response to virus by virus activated T cell proliferation T cell receptor signaling pathway leukocyte migration detection of mechanical stimulus involved in sensory perception of pain cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus positive regulation of protein localization to nucleus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand immune system process cell surface receptor signaling pathway multicellular organism development phosphorylation myelination protein autophosphorylation
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