Bioss

GADD153/DDIT3 Polyclonal Antibody, Alexa Fluor™ 647

查看其他24个CHOP抗体

产品信息

BS-20669R-A647

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-5,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

免疫组化（冰冻） (IHC (F))

1:50-1:200

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

流式细胞分析 (Flow)

1:20-1:100

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human GADD153/DDIT3

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偶联物

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

激发/发射光谱

650/671 nm 查看光谱

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.03% ProClin 300

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C/EBP homologous protein; C/EBP homoologous protein 10; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; DDIT-3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; Growth arrest and DNA damage-inducible protein GADD153; Growth arrest and DNA-damage-inducible protein GADD153; MGC4154

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基因别名: CEBPZ; CHOP; CHOP-10; CHOP10; DDIT3; GADD153

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UniProt ID: (Human) P35638, (Mouse) P35639

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Entrez Gene ID: (Human) 1649, (Mouse) 13198, (Rat) 29467

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transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding transcription factor binding cAMP response element binding protein binding protein homodimerization activity leucine zipper domain binding transcription regulatory region DNA binding protein heterodimerization activity sequence-specific DNA binding RNA polymerase II transcription factor binding

参与通路

negative regulation of transcription from RNA polymerase II promoter blood vessel maturation transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process ER overload response response to unfolded protein cell cycle cell cycle arrest Wnt signaling pathway endoplasmic reticulum unfolded protein response positive regulation of interleukin-8 production negative regulation of CREB transcription factor activity response to endoplasmic reticulum stress response to starvation mRNA transcription from RNA polymerase II promoter positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process regulation of transcription involved in anterior/posterior axis specification cell redox homeostasis negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter release of sequestered calcium ion into cytosol negative regulation of protein kinase B signaling intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of canonical Wnt signaling pathway positive regulation of neuron death negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress negative regulation of determination of dorsal identity response to amphetamine cellular response to DNA damage stimulus aging response to nutrient PERK-mediated unfolded protein response ATF6-mediated unfolded protein response response to drug response to hydrogen peroxide regulation of DNA-templated transcription in response to stress embryonic organ development positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to oxidative stress