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GADD45A Antibody (PA5-12383) in IHC (P)
Immunohistochemistry analysis of GADD45A in formalin-fixed and paraffin-embedded human tonsil tissue. Samples were incubated with GADD45A polyclonal antibody (Product # PA5-12383). This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-12383
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GADD45A
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2108064
产品详细信息
This antibody is predicted to react with bovine based on sequence homology.
靶标信息
GADD45 alpha, beta and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DDIT 1; DDIT-1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; Growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible, alpha
基因别名: DDIT1; GADD45; GADD45A
UniProt ID: (Human) P24522
Entrez Gene ID: (Human) 1647
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
activation of MAPKKK activity
DNA repair
negative regulation of protein kinase activity
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
centrosome cycle
signal transduction in response to DNA damage
positive regulation of apoptotic process
positive regulation of JNK cascade
cellular response to mechanical stimulus
cellular response to ionizing radiation
mitotic cell cycle arrest
positive regulation of p38MAPK cascade
positive regulation of reactive oxygen species metabolic process
