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产品信息
PA5-88248
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human GADD45A (NP_0019151)
偶联物
形式
Liquid
浓度
1.44 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804773
产品详细信息
Immunogen sequence: MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER; Positive Samples: HeLa, MCF7; Cellular Location: Nucleus
靶标信息
GADD45 alpha, beta and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DDIT 1; DDIT-1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage inducible transcript 1; DNA-damage-inducible transcript 1; Gadd45alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible, alpha
基因别名: AA545191; DDIT1; GADD45; GADD45A
UniProt ID: (Human) P24522, (Mouse) P48316
Entrez Gene ID: (Human) 1647, (Mouse) 13197, (Rat) 25112
activation of MAPKKK activity
negative regulation of protein kinase activity
response to stress
cellular response to DNA damage stimulus
cell cycle
cell cycle arrest
centrosome cycle
signal transduction in response to DNA damage
positive regulation of apoptotic process
positive regulation of JNK cascade
regulation of cell cycle
cellular response to ionizing radiation
mitotic cell cycle arrest
positive regulation of p38MAPK cascade
positive regulation of reactive oxygen species metabolic process
G2/M transition of mitotic cell cycle
cellular response to mechanical stimulus
regulation of cyclin-dependent protein serine/threonine kinase activity
DNA repair
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
