Product References
Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway.
Frontiers in neuroscience
Xue T,Wang S,Chen S,Wang H,Liu C,Shi L,Bai Y,Zhang C,Han C,Zhang J
PA1-988 was used in Western Blotting to investigate whether and how subthalamic nucleus inputs to the SNr regulate seizures and the role of the orexin pathway in this process.
Tue May 23 00:00:00 EDT 2023
Autophagy Alteration in ApoA-I Related Systemic Amyloidosis.
International journal of molecular sciences
Del Giudice R,Imbimbo P,Pietrocola F,Martins I,De Palma FDE,Bravo-San Pedro JM,Kroemer G,Maiuri MC,Monti DM
PA1-988 was used in Western Blotting to describe that the autophagic process is inhibited in the presence of the L75P-ApoA-I amyloidogenic variant in stably transfected human hepatocyte carcinoma cells.
Wed Mar 23 00:00:00 EDT 2022
Cacna2d2 inhibits axonal regeneration following surgical decompression in a rat model of cervical spondylotic myelopathy.
BMC neuroscience
Liu P,Li X,Liu J,Zhang H,You Z,Zhang J
PA1-988 was used in Western Blotting to show that inhibition of α2δ2 could enhance axonal recovery in anterior horn of damaged spinal cord induced by CSM after surgical decompression, providing a potential method for promoting axon regeneration following surgery.
Fri Jul 01 00:00:00 EDT 2022
CircRNA circYY1 (hsa_circ_0101187) Modulates Cell Glycolysis and Malignancy Through Regulating YY1 Expression by Sponging miR-769-3p in Breast Cancer.
Cancer management and research
Zhang X,Li J,Feng Q
PA1-988 was used in Western Blot to conclude that CircYY1 promoted glycolysis and tumor growth via increasing YY1 expression through sponging miR-769-3p in BC, offering a promising therapeutic target and prognostic biomarker for BC.
Wed Apr 20 00:00:00 EDT 2022
Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates.
Nature communications
Costa-Verdera H,Collaud F,Riling CR,Sellier P,Nordin JML,Preston GM,Cagin U,Fabregue J,Barral S,Moya-Nilges M,Krijnse-Locker J,van Wittenberghe L,Daniele N,Gjata B,Cosette J,Abad C,Simon-Sola M,Charles S,Li M,Crosariol M,Antrilli T,Quinn WJ,Gross DA,Boyer O,Anguela XM,Armour SM,Colella P,Ronzitti G,Mingozzi F
PA1-988 was used in Western Blotting to compare the efficacy of hepatic gene transfer with adeno-associated virus (AAV) vectors expressing secretable acid alpha-glucosidase with long-term enzyme replacement therapy.
Thu Nov 04 00:00:00 EDT 2021
Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates.
Nature communications
Costa-Verdera H,Collaud F,Riling CR,Sellier P,Nordin JML,Preston GM,Cagin U,Fabregue J,Barral S,Moya-Nilges M,Krijnse-Locker J,van Wittenberghe L,Daniele N,Gjata B,Cosette J,Abad C,Simon-Sola M,Charles S,Li M,Crosariol M,Antrilli T,Quinn WJ,Gross DA,Boyer O,Anguela XM,Armour SM,Colella P,Ronzitti G,Mingozzi F
PA1-988 was used in Western Blotting to compare the efficacy of hepatic gene transfer with adeno-associated virus (AAV) vectors expressing secretable acid alpha-glucosidase with long-term enzyme replacement therapy.
Thu Nov 04 00:00:00 EDT 2021
Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial-mesenchymal transition-related markers.
FEBS open bio
Li Y,Gong H,Feng L,Mao D,Xiao Y,Wang Y,Huang L
PA1-988 was used in Western Blotting to investigate the role of CHPF in breast carcinoma (BRCA) and its underlying mechanism.
Mon Feb 01 00:00:00 EST 2021
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Autophagy
Salazar G,Cullen A,Huang J,Zhao Y,Serino A,Hilenski L,Patrushev N,Forouzandeh F,Hwang HS
PA1-988 was used in Western Blot to investigate the role of the mitochondrial regulator PPARGC1A and SQSTM1/p62 in autophagy and senescence.
Mon Jun 01 00:00:00 EDT 2020
Small molecular compounds efficiently convert human fibroblasts directly into neurons.
Molecular medicine reports
Yang J,Cao H,Guo S,Zhu H,Tao H,Zhang L,Chen Z,Sun T,Chi S,Hu Q
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Tue Dec 01 00:00:00 EST 2020
DACH1, a novel target of miR-218, participates in the regulation of cell viability, apoptosis, inflammatory response, and epithelial-mesenchymal transition process in renal tubule cells treated by high-glucose.
Renal failure
Zhang YL,Wang JM,Yin H,Wang SB,He CL,Liu J
PA1-988 was used in Western Blotting to assess the functional role of miR-218/dachshund family transcription factor 1 (DACH1) in diabetic kidney disease (DKD) and investigate its possible molecular mechanism.
Sun Nov 01 00:00:00 EDT 2020
Gene therapy with secreted acid alpha-glucosidase rescues Pompe disease in a novel mouse model with early-onset spinal cord and respiratory defects.
EBioMedicine
Colella P,Sellier P,Gomez MJ,Biferi MG,Tanniou G,Guerchet N,Cohen-Tannoudji M,Moya-Nilges M,van Wittenberghe L,Daniele N,Gjata B,Krijnse-Locker J,Collaud F,Simon-Sola M,Charles S,Cagin U,Mingozzi F
PA1-988 was used in Western Blotting to show that the genetic background impacts on the severity of respiratory function and neuroglial spinal cord defects in the acidalpha-glucosidase (GAA) KO mouse model of Pompe disease (PD).
Sun Nov 01 00:00:00 EDT 2020
Gene therapy with secreted acid alpha-glucosidase rescues Pompe disease in a novel mouse model with early-onset spinal cord and respiratory defects.
EBioMedicine
Colella P,Sellier P,Gomez MJ,Biferi MG,Tanniou G,Guerchet N,Cohen-Tannoudji M,Moya-Nilges M,van Wittenberghe L,Daniele N,Gjata B,Krijnse-Locker J,Collaud F,Simon-Sola M,Charles S,Cagin U,Mingozzi F
PA1-988 was used in Western Blotting to show that the genetic background impacts on the severity of respiratory function and neuroglial spinal cord defects in the acidalpha-glucosidase (GAA) KO mouse model of Pompe disease (PD).
Sun Nov 01 00:00:00 EDT 2020
Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
Biomolecules
Deshpande A,Vinayakamoorthy RM,Garg BK,Thummapudi JP,Oza G,Adhikari K,Agarwal A,Dalvi P,Iyer S,Thulasi Raman S,Ramesh V,Rameshbabu A,Rezvaya A,Sukumaran S,Swaminathan S,Tilak B,Wang Z,Tran PV,Loring RH
PA1-988 was used in Western Blotting to find mouse macrophages bind αBGT but lack NACHO.
Thu Mar 19 00:00:00 EDT 2020
Inhibition of endogenous miR-23a/miR-377 in CHO cells enhances difficult-to-express recombinant lysosomal sulfatase activity.
Biotechnology progress
Amadi IM,Agrawal V,Christianson T,Bardliving C,Shamlou P,LeBowitz JH
PA1-988 was used in Western Blotting to demonstrate the importance of using miRNA to optimize the CHO cell line secreting DTE recombinant lysosomal sulfatase.
Fri May 01 00:00:00 EDT 2020
Engineered nanomedicine for neuroregeneration: light emitting diode-mediated superparamagnetic iron oxide-gold core-shell nanoparticles functionalized by nerve growth factor.
Nanomedicine : nanotechnology, biology, and medicine
Yuan M,Wang Y,Qin YX
PA1-988 was used in Western Blotting to report nerve growth factor functionalized superparamagnetic iron-oxide-gold core-shell nanoparticles (NGF-SPIO-Au NPs) as an engineered nanomedicine for non-invasive neuron regeneration when irradiated by a low-intensity light-emitting diode.
Tue Oct 01 00:00:00 EDT 2019
Deep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment.
Acta neuropathologica communications
Laforêt P,Inoue M,Goillot E,Lefeuvre C,Cagin U,Streichenberger N,Leonard-Louis S,Brochier G,Madelaine A,Labasse C,Hedberg-Oldfors C,Krag T,Jauze L,Fabregue J,Labrune P,Milisenda J,Nadaj-Pakleza A,Sacconi S,Mingozzi F,Ronzitti G,Petit F,Schoser B,Oldfors A,Vissing J,Romero NB,Nishino I,Malfatti E
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Mon Oct 28 00:00:00 EDT 2019
Downregulation of microRNA-205 inhibits cell invasion and angiogenesis of cervical cancer through TSLC1-mediated Akt signaling pathway.
Journal of cellular physiology
Zhang F,Liu J,Xie BB
PA1-988 was used in Western Blot to demonstrate that downregulated miR-205 inhibited cell invasion, migration, and angiogenesis in CC by inactivating the Akt signaling pathway via TSLC1 upregulation.
Thu Aug 01 00:00:00 EDT 2019
BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides.
Genes
Chakravarthy M,Veedu RN
PA1-988 was used in Western Blotting to develop a novel antisense oligonucleotide (AO) that could efficiently downregulate the transcript of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and partially inhibit the activity of the BACE1 protein.
Thu Sep 12 00:00:00 EDT 2019
AAV Gene Transfer with Tandem Promoter Design Prevents Anti-transgene Immunity and Provides Persistent Efficacy in Neonate Pompe Mice.
Molecular therapy. Methods & clinical development
Colella P,Sellier P,Costa Verdera H,Puzzo F,van Wittenberghe L,Guerchet N,Daniele N,Gjata B,Marmier S,Charles S,Simon Sola M,Ragone I,Leborgne C,Collaud F,Mingozzi F
PA1-988 was used in Western Blotting to develop tandem promoter monocistronic expression cassettes that can provide combined hepatic and extra-hepatic tissue-specific transgene expression and prevent anti-transgene immunity.
Fri Mar 15 00:00:00 EDT 2019
Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen.
Brain research
Brewer AL,Liu S,Buhler AV,Shirachi DY,Quock RM
PA1-988 was used in Western Blotting to show neurotransmitter γ-aminobutyric acid A may be involved in hyperbaric oxygen-induced antinociception at the γ-aminobutyric acid A receptor.
Thu Nov 15 00:00:00 EST 2018
Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen.
Brain research
Brewer AL,Liu S,Buhler AV,Shirachi DY,Quock RM
PA1-988 was used in Western Blotting to show neurotransmitter γ-aminobutyric acid A may be involved in hyperbaric oxygen-induced antinociception at the γ-aminobutyric acid A receptor.
Thu Nov 15 00:00:00 EST 2018
Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines.
Oncology letters
Li J
PA1-988 was used in Western Blotting to investigate the function of ROS proto-oncogene 1 receptor tyrosine kinase in regulating the migration and proliferation of acute myeloid leukaemia cells through Wnt/Β-catenin signalling, and in arsenic trioxide treatment.
Fri Jun 01 00:00:00 EDT 2018
Yersinia pestis Targets the Host Endosome Recycling Pathway during the Biogenesis of the Yersinia-Containing Vacuole To Avoid Killing by Macrophages.
mBio
Connor MG,Pulsifer AR,Chung D,Rouchka EC,Ceresa BK,Lawrenz MB
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Tue Feb 20 00:00:00 EST 2018
A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.
The Journal of biological chemistry
Yuan L,Singh D,Buescher JL,Arikkath J
PA1-988 was used in Western Blotting to conclude that by undergoing cleavage, δ-catenin differentially regulates the densities of subpopulations of dendritic spines and contributes to proper neural circuit wiring in the developing brain.
Fri Jul 20 00:00:00 EDT 2018
(-)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice.
Molecular nutrition & food research
De Los Santos S,García-Pérez V,Hernández-Reséndiz S,Palma-Flores C,González-Gutiérrez CJ,Zazueta C,Canto P,Coral-Vázquez RM
PA1988 was used in western blot to evaluate the effects of epicatechin in the normal heart
Wed Feb 01 00:00:00 EST 2017
Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Garg BK,Loring RH
PA1-988 was used in Western Blot to evaluate commercially available antibodies for rat α7 nicotinic acetylcholine receptors.
Fri Sep 01 00:00:00 EDT 2017
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.
Acta neuropathologica communications
Longo F,Mercatelli D,Novello S,Arcuri L,Brugnoli A,Vincenzi F,Russo I,Berti G,Mabrouk OS,Kennedy RT,Shimshek DR,Varani K,Bubacco L,Greggio E,Morari M
PA1988 was used in western blot to elucidate the effects of mutations in leucine-rich repeat kinase 2 on nigro0striatal dopamine neurons
Tue Mar 14 00:00:00 EDT 2017
Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor γ in MC3T3-E1 cells.
Biochemical and biophysical research communications
Qu B,Ma Y,Yan M,Gong K,Liang F,Deng S,Jiang K,Ma Z,Pan X
PA1-988 was used in western blot to investigate the molecular mechanism of Sirt1 in osteogenic differentiation
Fri Sep 09 00:00:00 EDT 2016
MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ-dependent manner.
Biochemical and biophysical research communications
Gong K,Qu B,Liao D,Liu D,Wang C,Zhou J,Pan X
PA1-988 was used in western blot to elucidate mechanisms by which miR-132 regulates osteogenic differentiation
Fri Sep 09 00:00:00 EDT 2016
Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk.
PloS one
Koch F,Lamp O,Eslamizad M,Weitzel J,Kuhla B
PA1-988 was used in western blot study feed intake and heat stress-related effects in cows
Mon Aug 07 00:00:00 EDT 2017
Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
eLife
Haven B,Heilig E,Donham C,Settles M,Vasilevsky N,Owen K
PA1-988 was used in western blot to discuss the findings of The Reproducibility Project: Cancer Biology
Tue Feb 23 00:00:00 EST 2016
Grape pomace extract exerts antioxidant effects through an increase in GCS levels and GST activity in muscle and endothelial cells.
International journal of molecular medicine
Goutzourelas N,Stagos D,Housmekeridou A,Karapouliou C,Kerasioti E,Aligiannis N,Skaltsounis AL,Spandidos DA,Tsatsakis AM,Kouretas D
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Sat Aug 01 00:00:00 EDT 2015
Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance.
PloS one
Verduzco D,Lloyd M,Xu L,Ibrahim-Hashim A,Balagurunathan Y,Gatenby RA,Gillies RJ
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Wed Feb 24 00:00:00 EST 2016
Selective in vivo targeting of human liver tumors by optimized AAV3 vectors in a murine xenograft model.
Human gene therapy
Ling C,Wang Y,Zhang Y,Ejjigani A,Yin Z,Lu Y,Wang L,Wang M,Li J,Hu Z,Aslanidi GV,Zhong L,Gao G,Srivastava A,Ling C
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Mon Dec 01 00:00:00 EST 2014
Selective in vivo targeting of human liver tumors by optimized AAV3 vectors in a murine xenograft model.
Human gene therapy
Ling C,Wang Y,Zhang Y,Ejjigani A,Yin Z,Lu Y,Wang L,Wang M,Li J,Hu Z,Aslanidi GV,Zhong L,Gao G,Srivastava A,Ling C
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Mon Dec 01 00:00:00 EST 2014
Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration.
Neurobiology of disease
Ma M,Ferguson TA,Schoch KM,Li J,Qian Y,Shofer FS,Saatman KE,Neumar RW
PA1-988 was used in western blot to study Wallerian degeneration and the role of calpains in the cytoskeletal disintegration of axons
Thu Aug 01 00:00:00 EDT 2013
Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury.
Journal of neurotrauma
Ma M,Shofer FS,Neumar RW
Published figure using GAPDH polyclonal antibody (Product # PA1-988) in Western Blot
Thu Nov 01 00:00:00 EDT 2012
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes.
Molecular pharmacology
Gary-Bobo M,Elachouri G,Scatton B,Le Fur G,Oury-Donat F,Bensaid M
PA1-988 was used in western blot to study the effect of rimonabant on enzyme content of mouse 3T3 F442A preadipocytes
Wed Feb 01 00:00:00 EST 2006
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.jpg?time=20240507?time=20240507 "GAPDH Antibody (PA1-988) in WB")
